The Cech Laboratory Research
 Members
 Alumni

Publications
[1973-1980] [1981-1985] [1986-1990] [1991-1995] [1996-2000] [2001-present]

2001

249. Silverman, S.K. and Cech, T.R. An Early Transition State for Folding of the P4-P6 RNA Domain. RNA7, 161-166

250. Juneau, K., Podell E., Harrington, D.J. and Cech, T.R. Strucutal Basis of the Enhanced Stability of a Mutant Ribozyme Domain and a Detailed View of RNA-Solvent Interactions Structure 9, 221-231

251. Cech, T.R. Overturning the Dogma: Catalytic RNA. In The Origins of Creativity, (Pfenninger, K.H. and Shubik, V.R. eds.) Oxford University Press , pp. 5-17

252. Baumann, P. and Cech, T.R. Pot1, the Putative Telomere End-binding Protein in Fission Yeast and Humans. Science 292, 1171-1175

253. Sperger, J.M. and Cech, A Stem-loop of Tetrahymena Telomerase RNA Distant from the Template Potentiates RNA Folding and Telomerase Activity. Biochemistry 40, 7005-7016

2002

254. Jarstfer, M.B. and Cech, T.R. Effects of Nucleotide Analogues on Euplotes aediculatus Telomerase Processivity: Evidence for Product-Assisted Translocation. Biochemistry 41, 151-161

255. Livengood, A.J., Zaug, A.J. and Cech, T.R. Essential Regions of Saccharomyces cerevisiae Telomerase RNA: Separate Elements for Est1p and Est2p Interaction. Molecular Cell Biology 22, 2366-2374

256. Guo, F. and Cech, T. R. In vivo Selection of Better Self-Splicing Introns in E. coli: the Role of the P1 Extension Helix of the Tetrahymena Intron. RNA 8, 647-658

257. Doudna, J. A. and Cech, T. R. The Chemical Repertoire of Natural Ribozymes. Nature 418, 222-228.

258. Baumann, P., Podell, E. and Cech, T. R. Human Pot1 (Protection of Telomeres) Protein: Cytolocalization Gene Structure, and Alternative Splicing. Molec. Cell. Biol. 22, 8079-8087

259. Guo, F. and Cech, T. R. Evolution of Tetrahymena Ribozyme Mutants with Increased Structural Stability. Nature Structural Biology 9, 855-961

260. Seto, A. G., Livengood, A. J., Tzfati, Y., Blackburn, E. H. and Cech, T. R. A Bulged Stem Tethers Est1p to Telomerase RNA in Budding Yeast. Genes Dev. 16, 2800-2812

261. Lei, M., Baumann, P. and Cech, T. R. Cooperative Binding of Single-stranded Telomeric DNA by Pot1 Protein of Schizosaccharomyces pombe. Biochemistry 41, 14560-14568

2003

262. Cech, T.R.  Ribozymes, The First 20 Years.  Biochemical Society Transactions 30, 1162-1166 (2002).

263. Friedman, K. L., Heit, J. J. , Long, D. L. and Cech, T. R.  N-terminal Domain of Yeast Telomerase Reverse Transcriptase: Recruitment of Est3p to the Telomerase Complex.  Molec. Biol. Cell 14, 1-13 (2003).

264. Förstemann, K., Zaug, A. J., Cech, T. R. and Lingner, J.  Yeast Telomerase is Specialized for C/A-rich RNA Templates.  Nucleic Acids Res. 31, 1646-1655 (2003).

265. Aigner, S., Postberg, J., Lipps, H. J. and Cech, T. R.  The Euplotes La Motif Protein p43 Has Properties of a Telomerase-Specific Subunit.  Biochemistry 42, 5736-5747 (2003).

266. Colgin, L. M., Baran, K., Baumann, P., Cech, T. R. and Reddel, R. R.  Human POT1 Facilitates Telomere Elongation by Telomerase.  Current Biology 13, 942-946 (2003).

267. Classen, S., Lyons, D., Cech, T. R. and Schultz, S. C.  Sequence Specific and 3'-end Selective Single Strand DNA Binding by the Oxytricha nova Telomere End Binding Protein a Subunit.  Biochemistry 42, 9269-9277 (2003).

268. Seto, A. G., Tzfati, Y., Zaug, A. J., Blackburn, E. H. and Cech, T. R. A Template-proximal RNA Paired Element Contributes to S. cerevisiae Telomerase Activity.  RNA 9, 1323-1332 (2003).

269. Lei, M., Podell, E. R., Baumann, P. and Cech, T. R.  DNA Self-recognition in the Structure of Pot1 Bound to Telomeric Single-stranded DNA.  Nature 426, 198-203 (2003).

270. Bryan, T. M., Goodrich, K. J. and Cech, T. R.  Tetrahymena telomerase is Active as a Monomer.  Molec. Biol. Cell 14, 4794-4804 (2003).
2004

271. Cech, T. R.  Beginning to Understand the End of the Chromosome (Review).  Cell 116, 273-279 (2004).

272. Cech, T. R.  RNA Finds a Simpler Way.  Nature 428, 263-264 (2004).

273. Zappulla, D. C. and Cech, T. R.  Yeast Telomerase RNA: A Flexible Scaffold for Protein Subunits.  Proc. Natl. Acad. Sci. USA 101, 10024-10029 (2004).

274. Aigner, S. and Cech, T. R.  The Euplotes Telomerase Subunit p43 Stimulates Enzymatic Activity and Processivity in vitro.  RNA 10, 1108-1118 2004

275. Guo, F., Gooding, A. R. and Cech, T. R.  Structure of the Tetrahymena Ribozyme: Base Triple Sandwich and Metal Ion at the Active Site.  Molec. Cell 16, 351-362 (2004).

276. Lei, M., Podell, E. R. and Cech, T. R.  Structure of Human POT1 Bound to Telomeric Single-stranded DNA provides a model for chromosome end-protection.  Nature Struc, Mol. Biol. 11, 1223-1229 (2004).

277. Mandell, J. G., Bähler, Volpe, T. A., Martienssen, R. A. and Cech, T. R.  Global Expression Changes Resulting from Loss of Telomeric DNA in Fission Yeast.  Genome Biol. 6, (2004).
2005

278. Mandell JG, Goodrich KJ, Bahler J and Cech T.R. Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase. J Biol Chem. 2005 Feb 18; 280(7):5249-57.

279. Mandell JG, Bahler J, Volpe TA, Martienssen RA and Cech T. R. Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome Biol. 2005;6(1):R1.

280. Lei M, Zaug AJ, Podell ER, and Cech T. R. Switching human telomerase on and off with hPOT1 protein in vitro. J Biol Chem. 2005 May 27;280(21):20449-56.

281. Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech T. R and Bohr VA. POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem. 2005 Sep 16;280(37):32069-80.

282. Zaug AJ, Podell ER and Cech TR. Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10864-9.

283. Jacobs SA, Podell ER, Wuttke DS and Cech T.R. Soluble domains of telomerase reverse transcriptase identified by high-throughput screening. Protein Sci. 2005 Aug;14(8):2051-8.

284. Cech T. R. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Biosci Rep. 2004 Aug-Oct;24(4-5):362-85.

285. Cech T. R. Fostering innovation and discovery in biomedical research. JAMA. 2005 Sep 21;294(11):1390-3.

286. Zappulla DC, Goodrich K and Cech T. R. A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro. Nat Struct Mol Biol. 2005 Dec;12(12):1072-7.
2006

287. Vicens Q and Cech T. R. Atomic level architecture of group I introns revealed. Trends Biochem Sci. 2006 Jan;31(1):41-51.

288. Guo F, Gooding AR and Cech T. R. Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme. RNA. 2006 Jan 23.

289. Jacobs SA, Podell ER and Cech T. R. Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nat Struct Mol Biol. 2006 Feb 5.

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